NDI-091143
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-127111-50 mg |
| CAS # | 2375840-87-0 |
| Pricing | 50 mg, USD $450.0 |
| Biological Activity | NDI-091143 is a potent and high-affinity human ATP-citrate lyase (ACLY) inhibitor with an IC50 of 2.1 nM (ADP-Glo assay), a Ki of 7.0 nM and a Kd of 2.2 nM. NDI-091143 inhibits ACLY catalysis allosterically, by stabilizing large conformational changes in the citrate domain that indirectly block the binding and recognition of citrate[1]. |
| Purity | 99.72% |
| MWt | 453.84 |
| Formula | C₂₀H₁₄ClF₂NO₅S |