| Supplier |
CD BioSciences |
| Product # |
AMA-0730 |
| Pricing |
20 µL/100 µL, Inquire
|
| Product Category |
Antibodies
|
| Application |
WB, IP
|
| Product Usage Information Dilution |
Western Blotting (1:1000); Immunoprecipitation (1:50)
|
| Reactivity |
Human, Mouse, Rat, Monkey
|
| Host |
Rabbit
|
| Gene ID |
64223
|
| UniProt ID |
|
| Source/Isotype |
Rabbit IgG
|
| MW (Target) |
37 kDa
|
| Storage |
Store at -20°C. Do not aliquot the antibody.
|
| Purification |
GβL (86B8) Rabbit mAb is produced by immunizing rabbits with a synthetic peptide corresponding to residues surrounding Gln210 of human GβL.
|
| Background |
Cell growth is a fundamental biological process whereby cells accumulate mass and increase in size. The mammalian Target of Rapamycin (mTOR) pathway regulates growth by coordinating energy and nutrient signals with growth factor-derived signals mTOR is a large protein kinase with two different complexes. One complex contains mTOR, GβL, and raptor, which is a target of rapamycin. The other complex, insensitive to rapamycin, includes mTOR, GβL, and rictor GβL associates with the kinase domain of mTOR and stimulates mTOR kinase activity A reduction in GβL expression has been shown to decrease in vivo phosphorylation of S6K1.
|