(±)-Asenapine-13C-d3 HCl
(±)-Asenapine-13C-d3 is intended for use as an internal standard for the quantification of (±)-asenapine by GC- or LC-MS. (±)-Asenapine is an atypical antipsychotic. It binds to dopamine D1-4, α-adrenergic, and histamine receptors, as well as the serotonin receptor subtypes 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT5A, 5-HT6, and 5-HT7. (±)-Asenapine inhibits the suppression of neuron firing induced by the 5-HT2A, dopamine D2, and α2-adrenergic receptor agonists 2,5-dimethoxy-4-iodoamphetamine, apomorphine, and clonidine, respectively, in rat brain. In vivo, (±)-asenapine increases extracellular dopamine levels in the medial prefrontal cortex, nucleus accumbens, and lateral striatum and suppresses the conditioned avoidance response in rats. It prevents acute and chronic phencyclidine-induced deficits in cued reversal learning in rats when administered at a dose of 0.075 mg/kg. Formulations containing asenapine have been used in the treatment of schizophrenia and bipolar I disorder.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD1414 |
| CAS # | 1261392-55-5 |
| Pricing | Customizable size, Inquiry |
| Synonym | (±)-Asenapine-13C-d3 HCl; |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C16(13C)H14D3Cl2NO |
| Exact Mass | 325.0909 |
| Molecular Weight | 326.2397 |
| Elemental Analysis | C, 62.89; H, 6.18; Cl, 21.73; N, 4.29; O, 4.90 |
| IUPAC/Chemical Name | (3aR,12bR)-5-chloro-2-(methyl-13C-d3)-2,3,3a,12b-tetrahydro-1H-dibenzo[2,3:6,7]oxepino[4,5-c]pyrrole hydrochloride |
| InChi Key | FNJQDKSEIVVULU-XSYCCUFUSA-N |
| InChi Code | InChI=1S/C17H16ClNO.ClH/c1-19-9-14-12-4-2-3-5-16(12)20-17-7-6-11(18)8-13(17)15(14)10-19;/h2-8,14-15H,9-10H2,1H3;1H/t14-,15-;/m0./s1/i1+1D3; |
| SMILES Code | [H][C@]12C3=C(OC4=C([C@@]1(CN(C2)[13C]([2H])([2H])[2H])[H])C=CC=C4)C=CC(Cl)=C3.Cl |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Shelf Life | >3 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |