Sitravatinib
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-16961-100 mg |
| CAS # | 1123837-84-2 |
| Pricing | 100 mg, USD $490.0 |
| Synonyms | MGCD516; MG-516 |
| MWt | 629.68 |
| Formula | C₃₃H₂₉F₂N₅O₄S |
| Biological Activity | Sitravatinib (MGCD516) is an orally bioavailable receptor tyrosine kinase (RTK) inhibitor with IC50s of 1.5 nM, 2 nM, 2 nM, 5 nM, 6 nM, 6 nM, 8 nM, 0.5 nM, 29 nM, 5 nM, and 9 nM for Axl, MER, VEGFR3, VEGFR2, VEGFR1, KIT, FLT3, DDR2, DDR1, TRKA, TRKB, respectively[1]. Sitravatinib shows potent single-agent antitumor efficacy and enhances the activity of PD-1 blockade through promoting an antitumor immune microenvironment[2]. |
| Purity | 99.85% |