Maprotiline-d3 hydrochloride
Maprotiline-d3 is intended for use as an internal standard for the quantification of maprotiline by GC- or LC-MS. Maprotiline is a tricyclic antidepressant. It binds to the norepinephrine transporter (NET) and is selective for NET over the serotonin and dopamine transporters. Maprotiline also binds to the serotonin (5-HT) receptor subtype 5-HT2A, as well as histamine H1, muscarinic acetylcholine, α1-adrenergic, and dopamine D2 receptors. In vivo, maprotiline inhibits norepinephrine reuptake in rat brain and peripheral tissues. It reduces isolation-induced aggressive behavior and inhibits electrical foot-shock stimulation-induced belligerence in mice when administered at doses ranging from 3 to 10 mg/kg. Maprotiline also reduces aggressive behavior in rhesus monkeys housed in groups. Formulations containing maprotiline have been used in the treatment of depression and anxiety.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD1343 |
| CAS # | 1329496-63-0 (hydrochloride) |
| Pricing | Customizable size, Inquiry |
| Synonym | Maprotiline-d3 hydrochloride; Maprotiline d3 hydrochloride; Ba 34276-d3; Ba34276-d3; Ba-34276-d3; Ba 34276 d3; |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C20H21D3ClN |
| Exact Mass | 316.1786 |
| Molecular Weight | 316.8873 |
| Elemental Analysis | C, 75.81; H, 8.59; Cl, 11.19; N, 4.42 |
| IUPAC/Chemical Name | 3-(9,10-ethanoanthracen-9(10H)-yl)-N-(methyl-d3)propan-1-amine hydrochloride |
| InChi Key | NZDMFGKECODQRY-NIIDSAIPSA-N |
| InChi Code | InChI=1S/C20H23N.ClH/c1-21-14-6-12-20-13-11-15(16-7-2-4-9-18(16)20)17-8-3-5-10-19(17)20;/h2-5,7-10,15,21H,6,11-14H2,1H3;1H/i1D3; |
| SMILES Code | [2H]C([2H])(NCCCC12CCC(C3=C2C=CC=C3)C4=CC=CC=C14)[2H].Cl |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |
| Class-2 | Anxiety |
| Availability | 2 Weeks |