15(S)-HETE
15(S)-HETE (HETE) is a metabolite of arachidonic acid via the 15-lipoxygenase pathway. In mammals, 15(S)-HETE is synthesized in the respiratory epithelium, leukocytes, and reticulocytes. 15(S)-HETE suppresses the incorporation of thymidine and biosynthesis of prostaglandin E2 in tumor cell cultures. Treatment of colon cancer cells with 15(S)-HETE inhibited cell proliferation and induced apoptosis, which was preceded by an increase in TGF-beta-inducible early gene (TIEG) and a decrease in Bcl-2.
| Supplier | BOC Sciences |
|---|---|
| Product # | 54845-95-3 |
| Pricing | Inquire |
| Cas | 54845-95-3 |
| Molecular Weight | 320.47 |
| Molecular Formula | C20H32O3 |
| Canonical SMILES | CCCCCC(C=CC=CCC=CCC=CCCCC(=O)O)O |