JH-RE-06
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-126214-10 mM * 1 mL |
| CAS # | 1361227-90-8 |
| Pricing | 10 mM * 1 mL, USD $588.0 |
| Biological Activity | JH-RE-06, a potent REV1-REV7 interface inhibitor (IC50=0.78 μM; Kd=0.42 μM), targets REV1 that interacts with the REV7 subunit of POLζ. JH-RE-06 disrupts mutagenic translesion synthesis (TLS) by preventing recruitment of mutagenic POLζ. JH-RE-06 improves chemotherapy[1][2]. |
| Purity | ≥98.0% |
| MWt | 468.72 |
| Formula | C₂₀H₁₆Cl₃N₃O₄ |