Lu AF21934
Lu AF21934 is a positive allosteric modulator of mGlu4 receptors. Lu AF21934 reduces the harmaline-induced hyperactivity but not tremor in rats. The actions of Lu AF21934 are 5-HT1A receptor-dependent. Activation of the mGlu4 receptor may be a promising mechanism for the development of novel antipsychotic drugs, efficacious toward positive, negative, and cognitive symptoms.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD936 |
| CAS # | 1445605-23-1 |
| Pricing | Customizable size, Inquiry |
| Synonym | Lu AF21934; Lu AF-21934; Lu AF 21934; Lu-AF21934; Lu-AF-21934; Lu-AF 21934; LuAF21934; LuAF-21934; LuAF 21934; |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C14H16Cl2N2O2 |
| Exact Mass | 314.0589 |
| Molecular Weight | 315.194 |
| Elemental Analysis | C, 53.35; H, 5.12; Cl, 22.49; N, 8.89; O, 10.15 |
| IUPAC/Chemical Name | (1S,2R)-N1-(3,4-Dichlorophenyl)cyclohexane-1,2-dicarboxamide |
| InChi Key | AVKZWCJNDWOBAM-ZJUUUORDSA-N |
| InChi Code | InChI=1S/C14H16Cl2N2O2/c15-11-6-5-8(7-12(11)16)18-14(20)10-4-2-1-3-9(10)13(17)19/h5-7,9-10H,1-4H2,(H2,17,19)(H,18,20)/t9-,10+/m1/s1 |
| SMILES Code | O=C([C@@H]1[C@H](C(N)=O)CCCC1)NC2=CC=C(Cl)C(Cl)=C2 |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |
| Availability | 2 Weeks |