JH295 hydrate
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-116423A-1 mg |
| Pricing | 1 mg, USD $700.0 |
| Biological Activity | JH295 hydrate is a potent, irreversible and selective NIMA-related kinase 2 (Nek2) inhibitor with an IC50 of 770 nM. JH295 hydrate inhibits cellular Nek2 via alkylation of Cys22. JH295 hydrate is inactive against the mitotic kinases, Cdk1, Aurora B or Plk1, and does not perturb bipolar spindle assembly or the spindle assembly checkpoint[1]. |
| Purity | ≥99.0% |
| MWt | 338.36 |
| Formula | C₁₈H₁₈N₄O₃ |