XAV-939
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-15147-10 mM * 1 mL |
| CAS # | 284028-89-3 |
| Pricing | 10 mM * 1 mL, USD $66.0 |
| Biological Activity | XAV-939 is a potent tankyrase inhibitor that targets Wnt/β-catenin signaling. XAV-939 stabilizes axin by inhibiting tankyrase 1 and tankyrase 2 (IC50s of 5 and 2 nM, respectively), thereby stimulating β-catenin degradation. XAV939 binds tightly to the catalytic (PARP) domains of TNKS1 and TNKS2 (Kds of 99 and 93 nM, respectively)[1]. |
| MWt | 312.31 |
| Formula | C₁₄H₁₁F₃N₂OS |