Nolatrexed dihydrochloride
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-108474-5 mg |
| CAS # | 152946-68-4 |
| Pricing | 5 mg, USD $70.0 |
| Synonyms | AG 337; Thymitaq |
| MWt | 357.26 |
| Formula | C₁₄H₁₄Cl₂N₄OS |
| Biological Activity | Nolatrexed dihydrochloride (AG 337) is a non-competitive lipophilic inhibitor of thymidylate synthase, interacts at the folate cofactor binding site of the enzyme, with a Ki of 11 nM for human thymidylate synthase[1]. Nolatrexed dihydrochloride (AG 337) induces cell cycle arrest in S phase of cancer cells. Anti-cancer activity[2]. |
| Purity | 98.21% |