A-966492
A-966492 is a potent PARP inhibitor that exhibits excellent potency against the PARP-1 enzyme in whole-cell assays with a K(i) of 1 nM and an EC(50) of 1 nM. Additionally, A-966492 has oral bioavailability across multiple species, crosses the blood-brain barrier, and appears to distribute into tumor tissue. It also demonstrated promising in vivo efficacy in combination with temozolomide in the B16F10 subcutaneous mouse melanoma model and as a single agent and in combination with carboplatin in the MX-1 breast cancer xenograft model.
| Supplier | Alfa Cytology |
|---|---|
| Product # | BC0001 |
| Pricing | 50.0 mg, 100.0 mg, 200.0 mg, 500.0 mg, 1.0 g, 2.0 g, inquire |