Amantadine sulfate
Amantadine is a drug that has U.S. Food and Drug Administration approval for use both as an antiviral and an anti-parkinsonian drug. Amantadine is a weak antagonist of the NMDA-type glutamate receptor, increases dopamine release, and blocks dopamine reuptake. Amantadine probably does not inhibit MAO enzyme. Moreover, the mechanism of its antiparkinsonian effect is poorly understood.[citation needed] The drug has many effects in the brain, including release of dopamine and norepinephrine from nerve endings. It appears to be a weak NMDA receptor antagonist as well as an anticholinergic, specifically a nicotinic alpha-7 antagonist like the similar pharmaceutical memantine.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD467 |
| CAS # | 31377-23-8 (sulfate) |
| Pricing | Customizable size, Inquiry |
| Synonym | 1-Adamantanamine Sulfate; |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C20H36N2O4S |
| Molecular Weight | 400.578 |
| Elemental Analysis | C, 59.97; H, 9.06; N, 6.99; O, 15.98; S, 8.00 |
| IUPAC/Chemical Name | Tricyclo(3.3.1.1(3,7))decan-1-amine, sulfate (2:1) |
| InChi Key | MYWTWSQFJLXGGQ-UHFFFAOYSA-N |
| InChi Code | InChI=1S/2C10H17N.H2O4S/c2*11-10-4-7-1-8(5-10)3-9(2-7)6-10;1-5(2,3)4/h2*7-9H,1-6,11H2;(H2,1,2,3,4) |
| SMILES Code | NC1(C2)CC3CC2CC(C3)C1.NC4(C5)CC6CC5CC(C6)C4.O=S(O)(O)=O |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |
| Class-2 | Schizophrenia |
| Availability | 2 Weeks |