bpV(phen) potassium hydrate
BpV(phen) is a bisperoxovanadium (bpV) compound which inhibits several different protein tyrosine phosphatases (PTPs) with IC50 of 38 nM. It also inhibits the vascular endothelial PTP-β with IC50 of 343 nM and PTP-1β with IC50 of 920 nM. At 0.1 mM, bpV(phen) inhibits SH2 domain-containing inositol 5'-phosphatase-2. Presumably by inhibiting insulin receptor kinase-associated PTPs, bpV(phen) activates the insulin receptor tyrosine kinase and promotes downstream signaling, including activation of PI3-kinase.
| Supplier | BOC Sciences |
|---|---|
| Product # | 171202-16-7 |
| Pricing | Inquire |
| Cas | 171202-16-7 |
| Molecular Weight | 404.3 |
| Molecular Formula | C12H8N2O5V·K+(H2O)3 |
| Canonical SMILES | O=[V+3]123([O-][O-]2)([O-][O-]3)[N]4=C(C([N]1=CC=C5)=C5C=C6)C6=CC=C4.O.O.O.[K+] |