Sepantronium Bromide (YM155)
Sepantronium Bromide(YM155) is a potent survivin suppressant by inhibiting Survivin promoter activity with IC50 of 0.54 nM in HeLa-SURP-luc and CHO-SV40-luc cells; does not significantly inhibit SV40 promoter activity, but is observed to slightly inhibit the interaction of Survivin with XIAP. YM155 down-regulates survivin and XIAP, modulates autophagy and induces autophagy-dependent DNA damage in breast cancer cells. Phase 2.
| Supplier | Selleck Chemicals |
|---|---|
| Product # | S1130 |
| Sku # | S1130-10mM/1mL |
| Pricing | 10mM/1mL, $112.00 |
Citations for this product:
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bioRxiv - Immunology 2024Quote: ... and survivin inhibitor sepantronium bromide (Nakahara et al., 2007) (10 nM YM155, S1130, Selleck Chemicals, Houston, TX) for 72h ...