Polyoxylglycerides
Polyoxylglycerides are inert liquid or semi-solid waxy materials and are amphiphilic in character. Caprylocaproyl polyoxylglycerides are pale-yellow oily liquids. Lauroyl polyoxylglycerides and stearoyl polyoxylglycerides occur as pale-yellow waxy solids. Oleoyl polyoxylglycerides and linoleoyl polyoxylglycerides occur as amber oily liquids, which may give rise to a deposit after prolonged periods at 20℃.
| Supplier | CD Formulation |
|---|---|
| Product # | PE-0562 |
| Pricing | , Inquire for price |
| product1 | Stabilizers |
| Applications | Polyoxylglycerides are used as self-emulsifying and solubilizing agents in oral and topical pharmaceutical formulations. They are also used in cosmetic and food products. |
| Safety | Polyoxylglycerides are used in oral and topical pharmaceutical formulations, and also in cosmetics and food products. They are generally regarded as relatively nonirritant and nontoxic materials. Caprylocaproyl polyoxylglycerides: LD50 (rat, oral): >22 ml/(kg day). Lauroyl polyoxylglycerides: LD50 (rat, oral): >2004 mg/(kg day). |
| Synonyms | Polyoxylglycerides are referred to as macrogolglycerides in Europe |
| CAS Number | / |
| Category | Emulsifying Agents; Nonionic Surfactant; Penetration Agents; Solubilizing Agents; Sustained-release Agents |
| Chemical Name | / |
| Grade | Pharmceutical Excipients |
| Administration route | Oral; topical; vaginal |
| Dosage Form | Oral route: capsules, tablets, solutions; topical route: emulsions, creams, lotions; vaginal route: emulsions, creams |
| Stability and Storage Conditions | Polyoxylglycerides are very stable and inert. However, preventive measures against the risk of oxidation or hydrolysis may be taken to ensure stability during handling. Polyoxylglycerides should be preserved in their original containers, and exposure to air, light, heat, and moisture should be prevented. |
| Source and Preparation | Polyoxylglycerides are obtained by partial alcoholysis of vegetable oils using macrogols, by esterification of glycerol and macrogols with unsaturated fatty acids, or by mixing glycerol esters and condensates of ethylene oxide with the fatty acids of the vegetable oil. |