PD0166285

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PD0166285 is a potent Wee1 and Chk1 inhibitor with activity at nanomolar concentrations (IC50=24 nM for Wee1 and 72 nM for Myt1). PD0166285 is also a novel G2 checkpoint abrogator. PD0166285 induces apoptosis.

Supplier	Selleck Chemicals
Product #	S8148
Sku #	S8148-25mg
Pricing	25mg, $697.00

Citations for this product:

Mild replication stress causes premature centriole disengagement via a sub-critical Plk1 activity under the control of ATR-Chk1

Devashish Dwivedi, Daniela Harry, Patrick Meraldi, bioRxiv - Cell Biology 2022

Quote: ... Wee1: 0.5 µM PD0166285 (Wee1i-1) (Selleck Chemicals: S8148), and Wee1 ...

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