AMD 3465
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-15971A |
| CAS # | 185991-24-6 |
| Pricing | inquire |
| Biological Activity | AMD 3465 (GENZ-644494) is a potent antagonist of CXCR4, inhibits binding of 12G5 mAb and CXCL12AF647 to CXCR4, with IC50s of 0.75 nM and 18 nM in SupT1 cells; AMD 3465 also potently inhibits the replication of X4 HIV strains (IC50: 1-10 nM), but has no effect on CCR5-using (R5) viruses. |
| Synonyms | GENZ-644494 |
| MWt | 410.6 |
| Formula | C₂₄H₃₈N₆ |