RU.521
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-114180-50 mg |
| CAS # | 2262452-06-0 |
| Pricing | 50 mg, USD $820.0 |
| Synonyms | RU320521 |
| MWt | 415.23 |
| Formula | C₁₉H₁₂Cl₂N₄O₃ |
| Biological Activity | RU.521 (RU320521) is a potent and selective cyclic GMP-AMP synthase (cGAS) inhibitor and inhibits cGAS-mediated interferon upregulation. RU.521 suppresses dsDNA-activated reporter activity with an IC50 of 700 nM. RU.521 reduces constitutive expression of interferon in macrophages from a mouse model of Aicardi-Goutières syndrome (AGS)[1]. |
| Purity | 98.24% |