Branaplam
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-19620-100 mg |
| CAS # | 1562338-42-4 |
| Pricing | 100 mg, USD $690.0 |
| Synonyms | LMI070; NVS-SM1 |
| MWt | 393.48 |
| Formula | C₂₂H₂₇N₅O₂ |
| Biological Activity | Branaplam (LMI070; NVS-SM1) is a highly potent, selective and orally active survival motor neuron-2 (SMN2) splicing modulator with an EC50 of 20 nM for SMN. Branaplam inhibits human-ether-a-go-go-related gene (hERG) with an IC50 of 6.3 μM. Branaplam elevates full-length SMN protein and extends survival in a severe spinal muscular atrophy (SMA) mouse model[1][2]. |
| Purity | 99.67% |