SEL120-34A monohydrochloride
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-111388A-10 mM * 1 mL |
| Pricing | 10 mM * 1 mL, USD $176.0 |
| Biological Activity | SEL120-34A monohydrochloride is an ATP-competitive and selective CDK8 inhibitor, inhibits kinase activities of CDK8/CycC and CDK19/CycC complexes with IC50s of 4.4 nM and 10.4 nM, respectively, with a Kd of 3 nM for CDK8. SEL120-34A monohydrochloride weakly inhibits CDK9 (calculated IC50=1070 nM), but shows no obvious activity against CDK1, 2, 4, 6, 5, 7. SEL120-34A monohydrochloride inhibits phosphorylation of STAT1 S727 and STAT5 S726[1]. Has anti-tumor activity[1]. |
| Purity | 99.98% |
| MWt | 450.6 |
| Formula | C₁₅H₁₉Br₂ClN₄ |