Prexasertib
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-18174-5 mg |
| CAS # | 1234015-52-1 |
| Pricing | 5 mg, USD $160.0 |
| Synonyms | LY2606368 |
| MWt | 365.39 |
| Formula | C₁₈H₁₉N₇O₂ |
| Biological Activity | Prexasertib (LY2606368) is a selective, ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor with a Ki of 0.9 nM and an IC50 of <1 nM. Prexasertib inhibits CHK2 (IC50=8 nM) and RSK1 (IC50=9 nM). Prexasertib causes double-stranded DNA breakage and replication catastrophe resulting in apoptosis. Prexasertib shows potent anti-tumor activity[1][2]. |
| Purity | 98.22% |