Calcium Alginate
Calcium alginate is an odorless or almost odorless, tasteless, white to pale yellowish-brown powder or fibers.
| Supplier | CD Formulation |
|---|---|
| Product # | PE-0558 |
| Pricing | , Inquire for price |
| product1 | Stabilizers |
| Molecular Formula | [(C6H7O6)2Ca]n |
| Molecular Weight | 195.16 (calculated); 219.00 (actual, average) |
| Applications | In pharmaceutical formulations, calcium alginate and calciumsodium alginate have been used as tablet disintegrants. The use of a high concentration (10%) of calcium-sodium alginate has been reported to cause slight speckling of tablets.A range of different types of delivery systems intended for oral administration have been investigated. |
| Safety | Calcium alginate is widely used in oral and topical formulations, and in foods. LD50 (rat, IP): 1.41 g/kg LD50 (rat, IV): 0.06 g/kg |
| Incompatibilities | Calcium alginate is incompatible with alkalis and alkali salts.Propranolol hydrochloride has been shown to bind to alginate molecules, suggesting that propranolol and calcium ions share common binding sites in the alginate chains; the formation of the calcium alginate gel structure was impeded in the presence of propranolol molecules. |
| Synonyms | Alginato calcico; alginic acid, calcium salt; algin; CA33; calc algin; calcium polymannuronate; Calginate; E404; Kaltostat |
| CAS Number | 9005-35-0 |
| Category | Emulsifying Agents; Stabilizing Agents; Tablet Dsintegrant; ThickeningAgents |
| UNII | 8P20S56HZI |
| Chemical Name | Calcium alginate |
| Grade | Pharmceutical Excipients |
| Administration route | Oral |
| Dosage Form | Oral Tablet |
| Stability and Storage Conditions | Calcium alginate can be sterilized by autoclaving at 115℃ for 30 minutes or by dry heat at 150℃ for 1 hour. Calcium alginate should be stored in airtight containers. |
| Source and Preparation | Calcium alginate can be obtained from seaweed, mainly species of Laminaria. Solutions of sodium alginate interact with an ionized calcium salt, resulting in the instantaneous precipitation of insoluble calcium alginate, which can then be further processed. Introducing varying proportions of sodium ions during manufacture can produce products having different absorption rates. |