(S,R,S)-AHPC-Me
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-112078 |
| CAS # | 1948273-02-6 |
| Pricing | inquire |
| Biological Activity | (S,R,S)-AHPC-Me (VHL ligand 2) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein[1]. (S,R,S)-AHPC-Me can be used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader. ARV-771 potently degrades BET protein in castration-resistant prostate cancer (CRPC) cells with a DC50 <1 nM[2]. |
| Synonyms | VHL ligand 2; E3 ligase Ligand 1A |
| MWt | 444.59 |
| Formula | C₂₃H₃₂N₄O₃S |