Tenofovir Alafenamide-[d5] Fumarate (diastereomers)

A labelled form of Tenofovir alafenamide fumarate. Tenofovir alafenamide fumarate, also known as Tenofovir alafenamide hemifumarate. TAF, GS-7340, is a nucleotide reverse transcriptase inhibitor and a novel prodrug of tenofovir. It is under development by Gilead Sciences for use in the treatment of HIV infection. Closely related to the commonly used reverse-transcriptase inhibitor tenofovir disoproxil fumarate (Viread), Tenofovir alafenamide has greater antiviral activity and better distribution into lymphoid tissues than that agent. Gilead has announced a phase 3 clinical trial evaluating a single-tablet regimen combining GS-7340 with cobicistat, emtricitabine and elvitegravir and plans to coformulate the drug with cobicistat, emtricitabine and the protease inhibitor darunavir.

• Supplier: BOC Sciences
• Product #: BLP-004580
• Molecular Weight: 481.50
• Molecular Formula: C25H28D5N6O9P