Avapritinib
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-101561-5 mg |
| CAS # | 1703793-34-3 |
| Pricing | 5 mg, USD $250.0 |
| Synonyms | BLU-285 |
| MWt | 498.56 |
| Formula | C₂₆H₂₇FN₁₀ |
| Biological Activity | Avapritinib (BLU-285) is a highly potent, selective, and orally active KIT and PDGFRA activation loop mutant kinases inhibitor with IC50s of 0.27 and 0.24 nM for KIT D816V and PDGFRA D842V, respectively. Avapritinib (BLU-285) binds the active conformation of the kinase and shows antitumor activity. Avapritinib (BLU-285) attenuates the transport function of both ABCB1 and ABCG2[1][2]. |
| Purity | 99.94% |