AAPK-25
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-126249 |
| CAS # | 2247919-28-2 |
| Pricing | inquire |
| Biological Activity | AAPK-25 is a potent and selective Aurora/PLK dual inhibitor with anti-tumor activity, which can cause mitotic delay and arrest cells in a prometaphase, reflecting by the biomarker histone H3Ser10 phosphorylation and followed by a surge in apoptosis. AAPK-25 targets Aurora-A, -B, and -C with Kd values ranging from 23-289 nM, as well as PLK-1, -2, and -3 with Kd values ranging from 55-456 nM[1]. |
| MWt | 442.32 |
| Formula | C₂₁H₁₃Cl₂N₃O₂S |