Drinabant
Drinabant, also known as AVE1625, is a selective CB1 receptor antagonist under investigation varyingly as a treatment for obesity, schizophrenia, Alzheimer's disease, Parkinson's disease, and nicotine dependence. AVE1625 may be useful to treat the cognitive deficits in schizophrenia and as a co-treatment with currently available antipsychotics. In addition, an improved side-effect profile was seen, with potential to ameliorate the EPS and weight gain issues with currently available treatments.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD190 |
| CAS # | 358970-97-5 |
| Pricing | Customizable size, Inquiry |
| Synonym | AVE1625; AVE 1625; AVE-1625; Drinabant. |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C23H20Cl2F2N2O2S |
| Exact Mass | 496.0591 |
| Molecular Weight | 497.3818 |
| Elemental Analysis | C, 55.54; H, 4.05; Cl, 14.25; F, 7.64; N, 5.63; O, 6.43; S, 6.45 |
| IUPAC/Chemical Name | N-(1-(bis(4-chlorophenyl)methyl)azetidin-3-yl)-N-(3,5-difluorophenyl)methanesulfonamide |
| InChi Key | IQQBRKLVEALROM-UHFFFAOYSA-N |
| InChi Code | InChI=1S/C23H20Cl2F2N2O2S/c1-32(30,31)29(21-11-19(26)10-20(27)12-21)22-13-28(14-22)23(15-2-6-17(24)7-3-15)16-4-8-18(25)9-5-16/h2-12,22-23H,13-14H2,1H3 |
| SMILES Code | CS(=O)(N(C1CN(C(C2=CC=C(Cl)C=C2)C3=CC=C(Cl)C=C3)C1)C4=CC(F)=CC(F)=C4)=O |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO, not in water |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |
| Class-2 | Schizophrenia |
| Availability | 2 Weeks |