PF-3450074

Supplier MedChemExpress
Product # HY-120072-25 mg
CAS # 1352879-65-2
Pricing 25 mg, USD $280.0
Synonyms PF-74
MWt 425.52
Formula C₂₇H₂₇N₃O₂
Biological Activity PF-3450074 (PF-74) is a specifical inhibitor of HIV-1 capsid protein (CA) and displays a broad-spectrum inhibition of HIV isolates with submicromolar potency (EC50=8-640 nM). PF-3450074 (PF-74) acts at an early stage of HIV-1 infection, inhibits viral replication by directly competing with the binding of CPSF6 and NUP153, and blocks the uncoating, assembly, and the reverse transcription steps of the viral life cycle[1][2]. CPSF6: nuclear host factors cleavage and polyadenylation specific factor 6; NUP153: nucleoporin 153.
Purity 99.20%
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