Peptide YY (3-36) (human) Acetate

• Supplier: Creative Peptides
• Product #: 10-101-96
• LabelingTarget: Neuropeptide Y Receptor
• Synonyms: PYY (3-36); Peptide YY; C16118; PYY3-36
• MolecularFormula: C180H279N53O54
• MolecularWeight: 4049.52
• Source: Synthetic
• Sequence: Ile-Lys-Pro-Glu-Ala-Pro-Gly-Glu-Asp-Ala-Ser-Pro-Glu-Glu-Leu-Asn-Arg-Tyr-Tyr-Ala-Ser-Leu-Arg-His-Tyr-Leu-Asn-Leu-Val-Thr-Arg-Gln-Arg-Tyr-NH2
• Explanation: The gut hormone peptide YY (3-36) is a 36-amino acid peptide secreted from L-cells in the intestinal mucosa of the ileum and large intestine in proportion to caloric intake.
• Application: PYY (3-36) plays an important role in the regulation of appetite control. It is assumed that this effect is mediated through Y2 receptors in the hypothalamic arcuate nucleus (ARC), a brain area responsible for the regulation of food intake. PYY (3-36) may represent a promising tool for the treatment of obesity.
• Reference:
  • The gut hormone peptide YY (PYY) belongs to the pancreatic polypeptide (PP) family along with PP and neuropeptide Y (NPY). These peptides mediate their effects through the NPY receptors of which there are several subtypes (Y1, Y2, Y4, and Y5). The L cells of the gastrointestinal tract are the major source of PYY, which exists in two endogenous forms: PYY(1-36) and PYY(3-36). The latter is produced by the action of the enzyme dipeptidyl peptidase-IV (DPP-IV). PYY(1-36) binds to and activates at least three Y receptor subtypes (Y1, Y2, and Y5), whereas PYY(3-36) is more selective for Y2 receptor (Y2R). The hypothalamic arcuate nucleus, a key brain area regulating appetite, has access to nutrients and hormones within the peripheral circulation.
  • Batterham, R. L., & Bloom, S. R. (2003). The gut hormone peptide YY regulates appetite. Annals of the New York Academy of Sciences, 994(1), 162-168.
• AreasOfInterest: Metabolic Disease
• LongTermStorageConditions: −20°C
• Disease: Obesity