Vercirnon sodium
Vercirnon sodium, a potent, selective and orally bioavailable CCR9 antagonist, inhibits CCR9-mediated Ca2+ mobilization and chemotaxis of MolT-4 cells with IC50s of 5.4 and 3.4 nM, respectively. Vercirnon sodium is more selective for CCR9 than CCR1-12 and CX3Cr1-7 (IC50s >10 µM for all). It is an equipotent inhibitor of CCL25-directed chemotaxis of both splice forms of CCR9 (CCR9A and CCR9B) with IC50s of 2.8 and 2.6 nM, respectively.
| Supplier | BOC Sciences |
|---|---|
| Product # | 886214-18-2 |
| Pricing | Inquire |
| Cas | 886214-18-2 |
| Molecular Weight | 466.91 |
| Molecular Formula | C22H20ClN2NaO4S |
| Canonical SMILES | CC(C)(C)C1=CC=C(C=C1)S(=O)(=O)[N-]C2=C(C=C(C=C2)Cl)C(=O)C3=CC=[N+](C=C3)[O-].[Na+] |