Adipic Acid

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Adipic acid occurs as a white or almost white, odorless nonhygroscopic crystalline powder. The crystal structure of adipic acid is monoclinic holohedral.
Supplier CD Formulation
Product # PE-0428
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product1 Pharmaceutical Excipients
Molecular Formula C6H10O4
Molecular Weight 146.14
Applications Adipic acid is used as an acidifying and buffering agent in intramuscular, intravenous and vaginal formulations. It is also used in food products as a leavening, pH-controlling, or flavoring agent. Adipic acid has been incorporated into controlled-release formulation matrix tablets to obtain pH-independent release for both weakly basic and weakly acidic drugs. It has also been incorporated into the polymeric coating of hydrophilic monolithic systems to modulate the intragel pH, resulting in zero-order release of a hydrophilic drug.The disintegration at intestinal pH of the enteric polymer shellac has been reported to improve when adipic acid was used as a pore-forming agent without affecting release in the acidic media.Other controlled-release formulations have included adipic acid with the intention of obtaining a late-burst release profile.
Safety
  • Adipic acid is used in pharmaceutical formulations and food products. The pure form of adipic acid is toxic by the IP route, and moderately toxic by other routes. It is a severe eye irritant, and may cause occupational asthma.
  • LD50 (mouse, IP): 0.28 g/kg
  • LD50 (mouse, IV): 0.68 g/kg
  • LD50 (mouse, oral): 1.9 g/kg
  • LD50 (rat, IP): 0.28 g/kg
  • LD50 (rat, oral): >11 g/kg
Incompatibilities Adipic acid is incompatible with strong oxidizing agents as well as strong bases and reducing agents. Contact with alcohols, glycols, aldehydes, epoxides, or other polymerizing compounds can result in violent reactions.
Synonyms Acidum adipicum; acifloctin; acinetten; adilactetten; asapic; 1, 4- butanedicarboxylic acid; E355; 1, 6-hexanedioic acid; Inipol DS.
CAS Number 124-04-9
Category Flavoring agent
UNII 76A0JE0FKJ
Chemical Name Hexanedioic acid
Administration route IM, IV, and vaginal
Dosage Form IM, IV, and vaginal preparations
Stability and Storage Conditions Adipic acid is normally stable but decomposes above boiling point.It should be stored in a tightly closed container in a cool, dry place, and should be kept away from heat, sparks, and open flame.
Source and Preparation Adipic acid is prepared by nitric acid oxidation of cyclohexanol or cyclohexanone or a mixture of the two compounds. Recently, oxidation of cyclohexene with 30% aqueous hydrogen peroxide under organic solvent- and halide-free conditions has been proposed as an environmentally friendly alternative for obtaining colorless crystalline adipic acid.
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