ZL006
ZL006 is a PSD95-nNOS protein-protein interaction inhibitor. ZL006 (EC50: 12.88 μM) directly inhibited binding of purified PSD95 and nNOS proteins in AlphaScreen without altering binding of PSD95 to ErbB4. ZL006 preferentially suppressed phase 2A pain behavior in the formalin test and suppressed allodynia induced by intraplantar complete Freund's adjuvant administration. Disrupting PSD95-nNOS protein-protein interactions is effective in attenuating pathological pain without producing unwanted side effects (i.e. motor ataxia) associated with NMDAR antagonists. (
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD1262 |
| CAS # | 1181226-02-7 |
| Pricing | Customizable size, Inquiry |
| Synonym | ZL006; ZL-006; ZL 006. |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C14H11Cl2NO4 |
| Exact Mass | 327.0065 |
| Molecular Weight | 328.145 |
| Elemental Analysis | C, 51.24; H, 3.38; Cl, 21.61; N, 4.27; O, 19.50 |
| IUPAC/Chemical Name | 4-(3,5-Dichloro-2-hydroxy-benzylamino)-2-hydroxybenzoic acid |
| InChi Key | RTEYSQSXRFVKTJ-UHFFFAOYSA-N |
| InChi Code | InChI=1S/C14H11Cl2NO4/c15-8-3-7(13(19)11(16)4-8)6-17-9-1-2-10(14(20)21)12(18)5-9/h1-5,17-19H,6H2,(H,20,21) |
| SMILES Code | O=C(O)C1=CC=C(NCC2=CC(Cl)=CC(Cl)=C2O)C=C1O |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | Soluble in DMSO |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | This drug may be formulated in DMSO |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |
| Availability | 2 Weeks |