PROTAC BET Degrader-1
PROTAC BET Degrader-1 (Compound 9) is a potent BET degrader based on PROTAC, decreases the level of BRD2, BRD3, and BRD4 proteins in RS4;11 cells at 3-10 nM, and inhibits the growth of this cell line with an IC50 of 4.3 nM, and 45.5 nM for MOLM-13 cells.
| Supplier | BOC Sciences |
|---|---|
| Product # | 2093386-22-0 |
| Pricing | Inquire |
| Cas | 2093386-22-0 |
| Molecular Weight | 871.9 |
| Molecular Formula | C44H45N11O9 |
| Canonical SMILES | CCN1C(=CC(=N1)C2CC2)NC3=NC(=NC4=C3C5=CC(=C(C=C5N4)C6=C(ON=C6C)C)OC)C(=O)NCCCCNC(=O)COC7=CC=CC8=C7C(=O)N(C8=O)C9CCC(=O)NC9=O |