IDH889

Supplier MedChemExpress
Product # HY-112289-100 mg
CAS # 1429179-07-6
Pricing 100 mg, USD $1800.0
Biological Activity IDH889 is an orally available, brain penetrant, allosteric and mutant specific inhibitor of isocitrate dehydrogenase 1 (IDH1). IDH889 has potent selectivity for IDH1 R132* mutations, with IC50s of 0.02 μM, 0.072 μM and 1.38 μM for IDH1R132H, IDH1R132C and IDH1wt, respectively. IDH889 shows potent cellular inhibition of R-2-hydroxyglutarate (2-HG) production with an IC50 of 0.014 μM[1].
Purity 98.25%
MWt 436.48
Formula C₂₃H₂₅FN₆O₂
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