IDH889
Supplier | MedChemExpress |
---|---|
Product # | HY-112289-100 mg |
CAS # | 1429179-07-6 |
Pricing | 100 mg, USD $1800.0 |
Biological Activity | IDH889 is an orally available, brain penetrant, allosteric and mutant specific inhibitor of isocitrate dehydrogenase 1 (IDH1). IDH889 has potent selectivity for IDH1 R132* mutations, with IC50s of 0.02 μM, 0.072 μM and 1.38 μM for IDH1R132H, IDH1R132C and IDH1wt, respectively. IDH889 shows potent cellular inhibition of R-2-hydroxyglutarate (2-HG) production with an IC50 of 0.014 μM[1]. |
Purity | 98.25% |
MWt | 436.48 |
Formula | C₂₃H₂₅FN₆O₂ |