Birinapant
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-16591-5 mg |
| CAS # | 1260251-31-7 |
| Pricing | 5 mg, USD $84.0 |
| Synonyms | TL32711 |
| MWt | 806.94 |
| Formula | C₄₂H₅₆F₂N₈O₆ |
| Biological Activity | Birinapant (TL32711), a bivalent Smac mimetic, is a potent antagonist for XIAP and cIAP1 with Kds of 45 nM and less than 1 nM, respectively. Birinapant (TL32711) induces the autoubiquitylation and proteasomal degradation of cIAP1 and cIAP2 in intact cells, which results in formation of a RIPK1: caspase-8 complex, caspase-8 activation, and induction of tumor cell death. Birinapant (TL32711) targets TRAF2-associated cIAPs and abrogates TNF-induced NF-κB activation. |
| Purity | ≥98.0% |