BAY 11-7082
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-13453-10 mM * 1 mL |
| CAS # | 19542-67-7 |
| Pricing | 10 mM * 1 mL, USD $66.0 |
| Synonyms | BAY 11-7821 |
| MWt | 207.25 |
| Formula | C₁₀H₉NO₂S |
| Biological Activity | BAY 11-7082 is an IκBα phosphorylation and NF-κB inhibitor. BAY 11-7082 selectively and irreversibly inhibits the TNF-α-induced phosphorylation of IκB-α, and decreases NF-κB and expression of adhesion molecules. BAY 11-7082 inhibits ubiquitin-specific protease USP7 and USP21 (IC50=0.19, 0.96 μM, respectively). BAY 11-7082 inhibits gasdermin D (GSDMD) pore formation in liposomes and inflammasome-mediated pyroptosis and IL-1β secretion in human and mouse cells[1][2][3][4][5]. |
| Purity | 99.98% |