Norfluoxetine-d5 HCl
Norfluoxetine-d5 is intended for use as an internal standard for the quantification of norfluoxetine by GC- or LC-MS. Norfluoxetine is an active metabolite of the antidepressant fluoxetine. It is formed from fluoxetine by the cytochrome P450 (CYP) isoforms CYP2C9, CYP2C19, and CYP3A. Norfluoxetine inhibits serotonin (5-HT) uptake in rat brain synaptosomal membrane preparations (Ki = 44.7 nM) and isolated human platelets (IC50 = ~15 nM). It has been found in the tissues of fish exposed to wastewater effluent.
| Supplier | Ace Therapeutics |
|---|---|
| Product # | SMD1086 |
| CAS # | 1185132-92-6 |
| Pricing | Customizable size, Inquiry |
| Synonym | Norfluoxetine-d5 HCl; Norfluoxetine d5 HCl; Norfluoxetine-d5 hydrochloride; Norfluoxetine d5 hydrochloride; Desmethylfluoxetine-d5; Desmethylfluoxetine d5; |
| Product Category | Lab-use Small Molecule Drugs |
| Chemical Formula | C16H12D5ClF3NO |
| Exact Mass | 336.1265 |
| Molecular Weight | 336.7937 |
| Elemental Analysis | C, 57.06; H, 6.58; Cl, 10.53; F, 16.92; N, 4.16; O, 4.75 |
| IUPAC/Chemical Name | 3-phenyl-3-(4-(trifluoromethyl)phenoxy)propan-1,1,2,2,3-d5-1-amine hydrochloride |
| InChi Key | GMTWWEPBGGXBTO-KDPCSTGBSA-N |
| InChi Code | InChI=1S/C16H16F3NO.ClH/c17-16(18,19)13-6-8-14(9-7-13)21-15(10-11-20)12-4-2-1-3-5-12;/h1-9,15H,10-11,20H2;1H/i10D2,11D2,15D; |
| SMILES Code | FC(F)(C1=CC=C(OC([2H])(C([2H])(C([2H])(N)[2H])[2H])C2=CC=CC=C2)C=C1)F.Cl |
| Appearance | Solid powder |
| Purity | >98% (or refer to the Certificate of Analysis) |
| Shipping Condition | Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. |
| Storage Condition | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Solubility | To be determined |
| Shelf Life | >2 years if stored properly |
| Drug Formulation | To be determined |
| Stock Solution Storage | 0 - 4℃ for short term (days to weeks), or -20℃ for long term (months). |
| HS Tariff Code | 2934.99.9001 |
| Availability | 2 Weeks |