Phospho-cdc2 (Tyr15) (10A11) Rabbit Antibody (BSA and Azide Free)

Supplier CD BioSciences
Product # AMA-0710
Pricing 100 µg, Inquire
Product Category Antibodies
Application WB, IF, F
Reactivity Human, Mouse, Rat, Monkey
Host Rabbit
Gene ID 983
UniProt ID
Source/Isotype Rabbit IgG
MW (Target) 34 kDa
Storage Store at -20°C. Do not aliquot the antibody.
Purification Monoclonal antibody is produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Tyr15 of human cdc2.
Background The entry of eukaryotic cells into mitosis is regulated by cdc2 kinase activation, a process controlled at several steps including cyclin binding and phosphorylation of cdc2 at Thr161 However, the critical regulatory step in activating cdc2 during progression into mitosis appears to be dephosphorylation of cdc2 at Thr14 and Tyr15 Phosphorylation at Thr14 and Tyr15, resulting in inhibition of cdc2, can be carried out by Wee1 and Myt1 protein kinases The cdc25 phosphatase may be responsible for removal of phosphates at Thr14 and Tyr15 and subsequent activation of cdc2.
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