Presenilin 1 (PSEN1) Antibody

PSEN1 Antibody is a Rabbit Polyclonal antibody against PSEN1. Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined.

• Supplier: Abbexa Ltd.
• Product #: abx001799-200UL
• Clonality: Polyclonal
• Conjugation: Unconjugated
• Host: Rabbit
• Tested Applications: WB, IHC, IF/ICC
• UniProt Primary AC: P49768
• Dry Ice: No
• Availability: Shipped within 5-10 working days.
• Note: This product is for research use only.