AG-494
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-101042-50 mg |
| CAS # | 133550-35-3 |
| Pricing | 50 mg, USD $280.0 |
| Synonyms | Tyrphostin AG 494 |
| MWt | 280.28 |
| Formula | C₁₆H₁₂N₂O₃ |
| Biological Activity | AG-494 (Tyrphostin AG 494) is a potent and selective EGFR tyrosine kinase inhibitor (IC50=0.7 μM). AG-494 inhibits the autophosphorylation of EGFR, ErbB2, HER1-2 and PDGF-R with IC50s 1.1, 39, 45 and 6 μM, respectively. AG-494 blocks Cdk2 activation and inhibits EGF-dependent DNA synthesis[1][2][3]. |
| Purity | 99.06% |