GSK-J4 hydrochloride
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-15648F-10 mg |
| CAS # | 1797983-09-5 |
| Pricing | 10 mg, USD $144.0 |
| Biological Activity | GSK-J4 hydrochloride is a potent dual inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A with IC50s of 8.6 and 6.6 μM, respectively. GSK-J4 hydrochloride inhibits LPS-induced TNF-α production in human primary macrophages with an IC50 of 9 μM. GSK-J4 hydrochloride is a cell permeable prodrug of GSK-J1[1][2][3]. |
| Purity | 98.83% |
| MWt | 453.96 |
| Formula | C₂₄H₂₈ClN₅O₂ |