Epiberberine chloride

Supplier MedChemExpress
Product # HY-N0226A-10 mM * 1 mL
CAS # 889665-86-5
Pricing 10 mM * 1 mL, USD $99.0
Biological Activity Epiberberine chloride is an alkaloid isolated from Coptis chinensis, acts as a potent AChE and BChE inhibitor, and a non-competitive BACE1 inhibitor, with IC50s of 1.07, 6.03 and 8.55 μM, respectively. Epiberberine chloride has antioxidant activity, with peroxynitrite ONOO- scavenging effect (IC50, 16.83 μM), and may protect against Alzheimer disease[1]. Epiberberine chloride inhibits the early stage of differentiation of 3T3-L1 preadipocytes, downregulates the Raf/MEK1/2/ERK1/2 and AMPKα/Akt pathways[2]. Epiberberine has the potential effect in the research of diabetic disease[3].
Purity 98.89%
MWt 371.81
Formula C₂₀H₁₈ClNO₄
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