Treosulfan-[d4]

Labelled Treosulfan. Treosulfan is the prodrug of a bifunctional sulfonate alkylating agent with myeloablative, immunosuppresive, and antineoplastic activities. Under physiological conditions, treosulfan converts nonenzymatically to L-diepoxybutane via a monoepoxide intermediate. The monoepoxide intermediate and L-diepoxybutane alkylate DNA at guanine residues and produce DNA interstrand crosslinks, resulting in DNA fragmentation and apoptosis. In escalated doses, this agent also exhbits myeloablative and immunosuppressive activities.

• Supplier: BOC Sciences
• Product #: BLP-007499
• Molecular Weight: 282.30
• Molecular Formula: C6H10D4O8S2
• Canonical SMILES: CS(=O)(=O)OCC(C(COS(=O)(=O)C)O)O