Recombinant Human IKK beta (N-GST tag)

IKK汕 is a serine/threonine protein kinase that phosphorylates the I-kappa-B protein which is an inhibitor of the transcription factor NF-kappa-B complex. Phosphorylation of I-kappa-B protein triggers the degradation of the inhibitor via the ubiquitination pathway, thereby activating NF-kappa-B complex. The activity of IKK汕 is stimulated by TNF and IL1 and IKK汕 forms a heterodimer that interacts with NIK. Overexpression of catalytically inactive IKK汕 blocks cytokine-induced NF-kappa-B activation. Aspirin and sodium salicylate can specifically inhibit IKK汕 activity in vitro and in vivo by binding to IKK汕 to reduce ATP binding.

• Supplier: Amerigo Scientific
• Product #: Z500177