Anti-Human MADCAM1 Therapeutic Antibody (PF-00547659)
Recombinant Humanized monoclonal antibody expressed in CHO binding to Human MADCAM1. PF-00547659 is an anti-human MAdCAM monoclonal antibody which has potential utility in the treatment of inflammatory conditions by blocking tissue homing of activated α4β7+ leukocytes. The characterization of a rodent cross-reacting antibody as a surrogate for PF-00547659 in the search for potential pharmacological biomarkers and the determination of efficacious doses was effective in addressing the restricted orthologous cross-reactivity of PF-00547659 and the challenges this poses with respect to efficacy and safety testing.
| Supplier | Creative Biolabs |
|---|---|
| Product # | TAB-509CL |
| Pricing | Inquiry |
| Target | MADCAM1 |
| Species Reactivity | Human |
| Type | Antibody |
| Applications | IHC, FuncS |
| Storage | Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles. |