Leriglitazone

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Supplier MedChemExpress
Product # HY-117727
CAS # 146062-44-4
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Biological Activity
  • Leriglitazone (Hydroxypioglitazone), a metabolite of pioglitazone.
  • Leriglitazone (Hydroxypioglitazone) PioOH is a PPARγ agonist, stabilizes the PPARγ activation function-2 (AF-2) co-activator binding surface and enhances co-activator binding, affording slightly better transcriptional efficacy.
  • Leriglitazone (Hydroxypioglitazone) binds to the PPARγ C-terminal ligand-binding domain (LBD) with Ki of 1.2 μM，induces transcriptional efficacy of the PPARγ (LBD) with EC50
  • of 680 nM[1].
Synonyms Hydroxypioglitazone
MWt 372.44
Formula C₁₉H₂₀N₂O₄S
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