FAK (D2R2E) Rabbit Antibody

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Supplier CD BioSciences
Product # AMA-0447
Pricing 100 µL, Inquire
Product Category Antibodies
Application WB, IP
Product Usage Information Dilution Western Blotting (1:1000); Immunoprecipitation (1:100)
Reactivity Human, Mouse
Host Rabbit
Gene ID 5747
UniProt ID
Source/Isotype Rabbit IgG
MW (Target) 125 kDa
Storage Store at -20°C. Do not aliquot the antibody.
Purification Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ser893 of human FAK protein.
Background Focal adhesion kinase (FAK) is a widely expressed cytoplasmic protein tyrosine kinase involved in integrin-mediated signal transduction. It plays an important role in the control of several biological processes, including cell spreading, migration, and survival Activation of FAK by integrin clustering leads to autophosphorylation at Tyr397, which is a binding site for the Src family kinases PI3K and PLCγ Recruitment of Src family kinases results in the phosphorylation of Tyr407, Tyr576, and Tyr577 in the catalytic domain, and Tyr871 and Tyr925 in the carboxy-terminal region of FAK.
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