PD-161570
| Supplier | MedChemExpress |
|---|---|
| Product # | HY-100434-5 mg |
| CAS # | 192705-80-9 |
| Pricing | 5 mg, USD $245.0 |
| Biological Activity | PD-161570 is a potent and ATP-competitive human FGF-1 receptor inhibitor with an IC50 of 39.9 nM and a Ki of 42 nM. PD-161570 also inhibits the PDGFR, EGFR and c-Src tyrosine kinases with IC50 values of 310 nM, 240 nM, and 44 nM, respectively. PD-161570 inhibits PDGF-stimulated autophosphorylation and FGF-1 receptor phosphorylation with IC50s of 450 nM and 622 nM, respectively[1][2]. PD-161570 is also a bone morphogenetic proteins (BMPs) and TGF-β signaling inhibitor[3]. |
| Purity | 99.04% |
| MWt | 532.51 |
| Formula | C₂₆H₃₅Cl₂N₇O |