Human Anti-TLR3 Recombinant Antibody (clone mAb12)
Recombinant Human Antibody (Mab12) is capable of binding to TLR3, expressed in HEK 293 cells. Expressed as the combination of a heavy chain (HC) containing VH from anti-TLR3 mAb and CH1-3 region of human IgG1 and a light chain (LC) encoding VL from anti-TLR3 proteins mAb and CL of human kappa light chain. Exists as a disulfide linked dimer of the HC and LC hetero-dimer under non-reducing condition. This antibody binds an epitope that overlaps the C-terminal dsRNA binding site and blocks the interaction of TLR3ecd with dsRNA, thus directly antagonizing TLR3 signaling through inhibition of SU formation.
| Supplier | Creative Biolabs |
|---|---|
| Product # | PABL-727 |
| Pricing | Inquiry |
| Host | Human |
| Target | TLR3 |
| Species Reactivity | Human |
| Type | Human IgG |
| Applications | WB, IHC, IF, FuncS |
| Storage | Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles. |